Ciências Farmacêuticas - Fful

Objectives

The aim of this curricular unit is to transmit the basic concepts of medicine, such as drug substance, its synthesis or extraction, excipient, pharmaceutical development and design, drug product, controls, bioavailability, and drug substance-receptor interactions. At the end of the course students should demonstrate integrated knowledge of the scientific principles that support the multidisciplinary field of Pharmaceutical Sciences in its different components, particularly pharmacology (pharmacodynamics), pharmacokinetics, medicinal/therapeutic chemistry and pharmaceutics.

Syllabus

1 - Medicine (drug product); Compounded medicines; Excipient, drug substance; Routes of Administration; Pharmacopoeias and Formularies 2 - Raw Materials; Pre-Formulation/Formulation Studies; Primary and secondary packaging, Stability; Manufacturing 3 - Pharmaceutical dosage forms 4 - Screening of compounds and chemical Libraries 5 - Acidic Drugs, Polyproptic and Amphenic Drugs; Ionization and Action Drug; Lipophilicity Descriptors 6 - Drug- Receptor; Dose/effect curves; Modulator Cellular Mechanisms; Characterization and Classification of Agonists; Dose/Response curves; Competitive Antagonist 7

• Non-Clinical Safety Assessment; Non-Clinical Development of a New Medicine; Non-Clinical Studies for Efficacy and Safety Assessment; Non-Clinical Strategy 8 - Absorption, distribution, metabolism and excretion of drugs; Compartmental and non-compartmental models; Bioavailability and bioequivalence; Administration of multiple doses

Prerequisites

Any student that has been admitted to the following 2nd Cycle programmes are eligible to take this course: MEFARM, MEQ, MEBIOL, MEBIOM or MEAMBI.

Cross Competence Component

This unit provides the skills necessary to be able to read, navigate and understand international GMP and Quality Systems legislation, across multiple regulatory regions, as a function of quality culture differences and its relation to patient safety, assurance in terms of therapeutic efficacy and their relation to product quality.

Programming And Computing Component

Advanced use of Excel (e.g., Solver for kinetic modelling).

Ethical Principles

All members of a group are responsible for the group’s work In any assessment every student shall honestly disclose any help received and sources used. In an oral assessment, every student shall be alble to present and answer questions about the entire assignment and solution.