Tecnologia dos Biomateriais

Objectives

Learning advanced concepts of materials science and engineering applied to the fields of bioengineering and biomedicine. At the end of this UC, the student should be able to, for a specific medical application targeted, to select materials and manufacture processes to provide adequate form and shape; understanding the relation between materials molecular structure and organization with bulk, surface and biological interface properties as well as the methods for their molecular synthesis, macroscopy processing and evaluation of materials chemical, physical and biological performance. Concepts will be consolidated in 6 laboratories hands-on work. Learning opportunities will be offered by a Medical Doctor expert on specific procedures and materials used on state of art medical practice. The biomaterials role in regenerative medicine will be highlight in case studies including students’ seminars.

Syllabus

This UC learning tracks are: 1.Sessions on state of art of biomaterials technologies based medical procedures; 2.Sessions on materials science and engineering concepts: a.the molecular structure, properties, and chemical synthesis and modification of the materials used in medicine -with emphasis on polymers; b.biocompatibility and other interactions between material and biological systems, namely material biodegradability and host response; c.methods to obtain 2D, 3D and nano structures and mimicking the extracellular matrix, including additive manufacture, cell encapsulation and 3D, and production of scaffolds for tissue engineering; and d.biomaterials applications, such as drug delivery, implants and scaffolds. 3.Wet laboratories on biomaterials preparation and characterization.

Cross Competence Component

The laboratory work requires strategic and critical thinking, as well as creativity and problem-solving strategies, competences evaluated along with the quality of the technical work developed, which requires the use of computer tools, and the quality of oral and written communication. The development of proactivity, initiative and ability to make decisions are competences promoted by the work on projects with open topics (seminar). Information and media literacy are promoted in the preparation of debates, seminars and reporting. Professional ethics, tolerance, openness and respect for diversity are promoted by working in multi-cultural teams and discussions and debate. Skills in oral and written communication, as well as teamwork, are promoted in seminars and laboratory projects. Skills on argumentation are initiated in the preparation of debates and discussions.

Laboratorial Component

Experimental work in the laboratory is focused on the preparation of various biomaterials: an elastomer and hydrogels, using different reticulation methods; Synthesis of a surgical glue, manufacturing of a hemodialysis menbrana, manufacture of an artificial tooth. Biomaterials obtained are characterized in their mechanical properties and water content. Hydrophobicity/hydrophilicity of the biomaterial surface is evaluated by contact angle measurements.

Ethical Principles

All members of a group are responsible for the group’s work In any assessment every student shall honestly disclose any help received and sources used. In an oral assessment, every student shall be alble to present and answer questions about the entire assignment and solution.